SOME SUBACUTE LIVER AND KIDNEY HAZARDS BY TECHNICAL METALAXYL IN MALE ALBINO RATS

The present study aimed to evaluate biochemically and
histopathologically some subacute toxicity aspects for livers and
kidneys of albino rats treated with four different doses (50, 100, 150,
200ppm) from the technical fungicide metalaxyl (95%). The
biochemical results in respect to liver function showed significant
increase in AST enzyme activity after two weeks of treatment with the
dose levels 50,150ppm, significant increase in ALT enzyme activity
after the first week with the dose levels 50,100,150ppm. Also ALP
enzyme activity was increased significantly by the dose level 50 ppm
after one week of treatment. In respect of kidney function the data
showed significant increase in urea concentration with the dose level
100ppm after one week of treatment , with the dose level 50ppm after
the second week, with the dose levels 50,100ppm after the third week
and with the dose levels 150,200ppm after the fourth week . Plasma
calcium concentration was increased significantly by all used dose
levels after the first week of treatment and by the dose levels
100,150ppm after the second week .Also plasma phosphorus
concentration was decreased significantly by the dose levels
50,100ppm after the first week of treatment. Most of these changes
were disappeared after the recovery period. The liver
histopathological examination at the end of treatment period showed
some necrosis and vacuolar degeneration change , congestion of blood
vessels , infiltration of mononuclear inflammatory cells , thrombus
formation in the blood vessels , newly formed bile ductless , sever
hemorrhage and peknosis. Kidney tissues showed congestion in blood
SOME SUBACUTE LIVER AND KIDNEY HAZARDS324
vessels, necrosis in some cells lining renal tubules, slight hemorrhage,
swelling in wall of blood vessels and infiltration of mononuclear
inflammatory cells around the glumeular